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Review: moderate weight loss reduces functional disability but does not reduce pain in obese patients with knee osteoarthritis

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R Christensen

Correspondence to: Mr R Christensen, Parker Institute, Musculoskeletal Statistics Unit, Frederiksberg Hospital, Frederiksberg, Denmark;


In obese patients with knee osteoarthritis (OA), does weight loss reduce pain and improve functional disability?


Data sources:

MEDLINE (1966 to April 2006), EMBASE/Excerpta Medica (1980 to April 2006), CINAHL (1982 to April 2006), Web of Science (1945 to April 2006), Scopus (1966 to May 2006), Cochrane Musculoskeletal Group’s trials register, Cochrane Central Register of Controlled Trials, conference abstracts, and reference lists.

Study selection and assessment:

randomised controlled trials (RCTs) that evaluated any intervention reporting weight change as the only difference between the treatment and control groups in obese patients with knee OA. Concomitant treatments (eg, medication, exercise, or …

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  • Source of funding: Oak Foundation; H:S Research Foundation; Danish Rheumatism Association.