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  • An intensive lifestyle intervention reduced weight and cardiovascular disease risk factors in overweight and obese people with type 2 diabetesCommentary

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An intensive lifestyle intervention reduced weight and cardiovascular disease risk factors in overweight and obese people with type 2 diabetes

http://dx.doi.org/10.1136/ebn.11.1.16

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    M Espeland

    Correspondence to: Dr M Espeland, Wake Forest University School of Medicine, Winston-Salem, NC, USA; mespelan@wfubmc.edu

    QUESTION

    In overweight or obese people with type 2 diabetes, does an intensive lifestyle intervention reduce weight and cardiovascular disease risk factors?

    METHODS

    Design:

    randomised controlled trial (Action for Health in Diabetes [Look AHEAD] trial).

    Allocation:

    {concealed}.*

    Blinding:

    {data collectors and outcome assessors}.*

    Follow-up period:

    1 year.

    Setting:

    16 centres in the US.

    Participants:

    5145 participants 45–75 years of age (mean age 59 y, 60% women) with type 2 diabetes and body mass index >25 kg/m2 or >27 kg/m2 if taking insulin.

    Intervention:

    intensive lifestyle intervention (n = 2570) or diabetes support and education (n = 2575). The lifestyle intervention combined calorie restriction (⩽30% fat; …

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    Footnotes

    • Source of funding: National Institutes of Health.