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M Espeland
Correspondence to: Dr M Espeland, Wake Forest University School of Medicine, Winston-Salem, NC, USA; mespelan@wfubmc.edu
QUESTION
In overweight or obese people with type 2 diabetes, does an intensive lifestyle intervention reduce weight and cardiovascular disease risk factors?
METHODS
Design:
randomised controlled trial (Action for Health in Diabetes [Look AHEAD] trial).
Allocation:
{concealed}.*
Blinding:
{data collectors and outcome assessors}.*
Follow-up period:
1 year.
Setting:
16 centres in the US.
Participants:
5145 participants 45–75 years of age (mean age 59 y, 60% women) with type 2 diabetes and body mass index >25 kg/m2 or >27 kg/m2 if taking insulin.
Intervention:
intensive lifestyle intervention (n = 2570) or diabetes support and education (n = 2575). The lifestyle intervention combined calorie restriction (⩽30% fat; …
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