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An intensive lifestyle intervention reduced weight and cardiovascular disease risk factors in overweight and obese people with type 2 diabetes

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M Espeland

Correspondence to: Dr M Espeland, Wake Forest University School of Medicine, Winston-Salem, NC, USA;


In overweight or obese people with type 2 diabetes, does an intensive lifestyle intervention reduce weight and cardiovascular disease risk factors?



randomised controlled trial (Action for Health in Diabetes [Look AHEAD] trial).




{data collectors and outcome assessors}.*

Follow-up period:

1 year.


16 centres in the US.


5145 participants 45–75 years of age (mean age 59 y, 60% women) with type 2 diabetes and body mass index >25 kg/m2 or >27 kg/m2 if taking insulin.


intensive lifestyle intervention (n = 2570) or diabetes support and education (n = 2575). The lifestyle intervention combined calorie restriction (⩽30% fat; …

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  • Source of funding: National Institutes of Health.