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Decontamination of the nasopharynx and oropharynx with chlorhexidine reduced nosocomial infections in cardiac surgery

https://doi.org/10.1136/ebn.10.4.115

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    Segers P, Speekenbrink RG, Ubbink DT, et al. Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial. JAMA 2006;296:2460–6.OpenUrlCrossRefPubMedWeb of Science

    Q Does perioperative decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate reduce nosocomial infections after cardiac surgery?

    METHODS

    Embedded ImageDesign:

    randomised, placebo-controlled trial.

    Embedded ImageAllocation:

    concealed.

    Embedded ImageBlinding:

    blinded (patients, healthcare providers, data collectors, {outcome assessors, data analysts, safety and monitoring committee, and manuscript writers}*).

    Embedded ImageFollow-up period:

    up to 30 days.

    Embedded ImageSetting:

    a community hospital in the Netherlands.

    Embedded ImagePatients:

    991 patients >18 years of age requiring cardiothoracic surgery. Exclusion criteria included emergency procedures; preoperative infection or use of antimicrobials; …

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    Footnotes

    • ↵* Information provided by author.

    • For correspondence: Dr P Segers, University of Amsterdam, Amsterdam, the Netherlands. p.segers{at}amc.uva.nl

    • Source of funding: no external funding.