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Decontamination of the nasopharynx and oropharynx with chlorhexidine reduced nosocomial infections in cardiac surgery

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Q Does perioperative decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate reduce nosocomial infections after cardiac surgery?


Embedded ImageDesign:

randomised, placebo-controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded (patients, healthcare providers, data collectors, {outcome assessors, data analysts, safety and monitoring committee, and manuscript writers}*).

Embedded ImageFollow-up period:

up to 30 days.

Embedded ImageSetting:

a community hospital in the Netherlands.

Embedded ImagePatients:

991 patients >18 years of age requiring cardiothoracic surgery. Exclusion criteria included emergency procedures; preoperative infection or use of antimicrobials; …

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  • * Information provided by author.

  • For correspondence: Dr P Segers, University of Amsterdam, Amsterdam, the Netherlands. p.segers{at}

  • Source of funding: no external funding.