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The Atkins diet led to more weight loss than the Zone diet in overweight and obese premenopausal women at 12 months

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Q What is the relative effectiveness of Atkins, Zone, “Lifestyle, Exercise, Attitudes, Relationships, and Nutrition (LEARN),” and Ornish diets for weight loss in overweight or obese premenopausal women?


Embedded ImageDesign:

randomised controlled trial (Atkins, Traditional, Ornish, Zone [A TO Z] Weight Loss Study).

Embedded ImageAllocation:

unclear allocation concealment.

Embedded ImageBlinding:

blinded {data collectors, data analysts, and safety and monitoring committee}.*

Embedded ImageFollow-up period:

12 months.

Embedded ImageSetting:

United States.

Embedded ImagePatients:

311 premenopausal women 25–50 years of age (mean age 41 y, 71% white) who were overweight or obese (body mass index [BMI] 27–40 kg/m2), had stable weight in the …

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  • * Information provided by author.

  • For correspondence: Dr C D Gardner, Stanford University Medical School, Stanford, CA, USA. cgardner{at}

  • Sources of funding: National Institutes of Health, Community Foundation of Southeastern Michigan, Human Health Services.