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randomised controlled trial.
blinded (patients, healthcare providers, and respiratory therapists). The respiratory care practitioner who assessed readiness for weaning was not blinded.
Follow up period:
to hospital discharge or death.
intensive care units (ICUs) of 3 hospitals in the US and Canada.
304 patients >18 years of age (mean age 65 y, 54% men) who had acute respiratory failure and had been on mechanical ventilation for ⩾24 hours (median 2 d). Exclusion criteria included expected survival <48 hours and primary neurological event without expectation for recovery.
all patients …
For correspondence: Dr M A Tanios, UCLA School of Medicine, St Mary Medical Center, Long Beach, CA, USA.
Source of funding: not stated.