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Daily folic acid supplementation for 3 years reduced age related hearing loss

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Q Is daily folic acid supplementation for 3 years more effective than placebo for reducing age related hearing loss in older adults?


Embedded ImageDesign:

substudy of a randomised, placebo controlled trial (Folic Acid and Carotid Intima media Thickness trial [FACIT]).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, statisticians, data safety and monitoring committee, and manuscript writers}.*

Embedded ImageFollow up period:

3 years.

Embedded ImageSetting:

Gelderland province, the Netherlands.

Embedded ImageParticipants:

819 participants 50–70 years of age (mean age 60 y, 72% men) with total plasma homocysteine concentrations of 13–26 μmol/l and serum vitamin B12 concentrations ⩾200 pmol/l were recruited using municipal and local blood bank registries. 48 participants had ⩾1 household member who was also enrolled …

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  • * Information provided by author.

  • For correspondence: Dr J Durga, Nestlé Research Center, Lausanne, Switzerland. jane.durga{at}

  • Sources of funding: the Netherlands Organisation for Health Research and Development and Wageningen Centre for Food Sciences.