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Daily folic acid supplementation for 3 years reduced age related hearing loss

http://dx.doi.org/10.1136/ebn.10.3.88

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    Durga J, Verhoef P, Anteunis LJ, et al. Effects of folic acid supplementation on hearing in older adults: a randomized, controlled trial. Ann Intern Med 2007;146:1–9.OpenUrlCrossRefPubMed

    Q Is daily folic acid supplementation for 3 years more effective than placebo for reducing age related hearing loss in older adults?

    METHODS

    Embedded ImageDesign:

    substudy of a randomised, placebo controlled trial (Folic Acid and Carotid Intima media Thickness trial [FACIT]).

    Embedded ImageAllocation:

    concealed.

    Embedded ImageBlinding:

    blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, statisticians, data safety and monitoring committee, and manuscript writers}.*

    Embedded ImageFollow up period:

    3 years.

    Embedded ImageSetting:

    Gelderland province, the Netherlands.

    Embedded ImageParticipants:

    819 participants 50–70 years of age (mean age 60 y, 72% men) with total plasma homocysteine concentrations of 13–26 μmol/l and serum vitamin B12 concentrations ⩾200 pmol/l were recruited using municipal and local blood bank registries. 48 participants had ⩾1 household member who was also enrolled …

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    Footnotes

    • ↵* Information provided by author.

    • For correspondence: Dr J Durga, Nestlé Research Center, Lausanne, Switzerland. jane.durga{at}rdls.nestle.com

    • Sources of funding: the Netherlands Organisation for Health Research and Development and Wageningen Centre for Food Sciences.