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4 layer bandages were better than 1 layer bandages, and pentoxifylline may be better than placebo for venous leg ulcers

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Q In patients with venous leg ulcers, which drug, bandage, and dressing options are most effective for healing?


Embedded ImageDesign:

2×2×2 factorial randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

partially blinded (patients and healthcare providers were blinded to the drug intervention only).

Embedded ImageFollow up period:

24 weeks.

Embedded ImageSetting:

2 centres in Scotland, UK.

Embedded ImagePatients:

245 patients >18 years of age (mean age 70 y, 67% women) with clinical signs of venous disease and a venous leg ulcer ⩾1 cm in length and ⩾8 weeks in duration. Exclusion criteria included important arterial disease, …

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  • For correspondence: Dr E A Nelson, University of Leeds, Leeds, UK. e.a.nelson{at}

  • Sources of funding: ConvaTec UK Ltd, Hoeschst Roussel Ltd UK, and Chief Scientist Office, Scotland.