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  • Review: adequately randomised trials showed that mammography screening did not significantly reduce breast cancer, cancer, or all cause mortality but increased breast surgeries

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Review: adequately randomised trials showed that mammography screening did not significantly reduce breast cancer, cancer, or all cause mortality but increased breast surgeries

https://doi.org/10.1136/ebn.10.3.80

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    Gøtzsche PC, Nielsen M. Screening for breast cancer with mammography. Cochrane Database Syst Rev 2006;(4):CD001877.OpenUrlPubMed

    Q Does screening for breast cancer with mammography reduce morbidity and mortality?

    METHODS

    Embedded ImageData sources:

    PubMed (June 2005) and review of reference lists.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) that compared mammography screening with no mammography screening in women without previously diagnosed breast cancer. 7 trials met the selection criteria; 2 had adequate randomisation, 4 had sub-optimal randomisation, and 1 was not adequately randomised. Separate analyses were done for adequately and sub-optimally randomised trials.

    Embedded ImageOutcomes:

    breast cancer mortality, cancer mortality, all cause mortality, surgical interventions, and adjuvant therapy.

    MAIN RESULTS

    Meta-analysis showed …

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    Footnotes

    • For correspondence: Dr P Gøtzsche, Nordic Cochrane Centre, Copenhagen, Denmark. pcg{at}cochrane.dk

    • Source of funding: Danish Institute for Health Technology Assessment.