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PubMed (June 2005) and review of reference lists.
Study selection and assessment:
randomised controlled trials (RCTs) that compared mammography screening with no mammography screening in women without previously diagnosed breast cancer. 7 trials met the selection criteria; 2 had adequate randomisation, 4 had sub-optimal randomisation, and 1 was not adequately randomised. Separate analyses were done for adequately and sub-optimally randomised trials.
breast cancer mortality, cancer mortality, all cause mortality, surgical interventions, and adjuvant therapy.
Meta-analysis showed …
For correspondence: Dr P Gøtzsche, Nordic Cochrane Centre, Copenhagen, Denmark.
Source of funding: Danish Institute for Health Technology Assessment.