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Review: oral anticoagulants plus aspirin reduce arterial thromboembolism more than oral anticoagulants alone but only in patients with mechanical heart valves

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Q In adults requiring oral anticoagulant (OAC) therapy, what is the relative efficacy and safety of OACs plus aspirin compared with OACs alone?


Embedded ImageData sources:

Medline (1966 to June 2005), EMBASE/Excerpta Medica (1980 to June 2005), Cochrane Central Register of Controlled Trials (Issue 2, 2005), reference lists, and experts.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) that compared OACs plus aspirin with OACs alone (where OACs were administered to achieve the same target international normalised ratio [INR] or with the same fixed dose in both treatment arms) in adults requiring OAC therapy and that reported ⩾1 …

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  • For correspondence: Dr J D Douketis, St Joseph’s Hospital, Hamilton, Ontario, Canada. jdouket{at}

  • Source of funding: no external funding.