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  • Review: oral anticoagulants plus aspirin reduce arterial thromboembolism more than oral anticoagulants alone but only in patients with mechanical heart valves

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Review: oral anticoagulants plus aspirin reduce arterial thromboembolism more than oral anticoagulants alone but only in patients with mechanical heart valves

http://dx.doi.org/10.1136/ebn.10.3.79

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    Dentali F, Douketis JD, Lim W, et al. Combined aspirin−oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials. Arch Intern Med 2007;167:117–24.OpenUrlCrossRefPubMedWeb of Science

    Q In adults requiring oral anticoagulant (OAC) therapy, what is the relative efficacy and safety of OACs plus aspirin compared with OACs alone?

    METHODS

    Embedded ImageData sources:

    Medline (1966 to June 2005), EMBASE/Excerpta Medica (1980 to June 2005), Cochrane Central Register of Controlled Trials (Issue 2, 2005), reference lists, and experts.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) that compared OACs plus aspirin with OACs alone (where OACs were administered to achieve the same target international normalised ratio [INR] or with the same fixed dose in both treatment arms) in adults requiring OAC therapy and that reported ⩾1 …

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    Footnotes

    • For correspondence: Dr J D Douketis, St Joseph’s Hospital, Hamilton, Ontario, Canada. jdouket{at}mcmaster.ca

    • Source of funding: no external funding.