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Medline (to 2005), reference lists, abstracts of scientific meetings, and drug manufacturers.
Study selection and assessment:
English language randomised controlled trials (RCTs) that compared an antacid, alginate-antacid combination, or histamine-2 receptor antagonist (H2RA) at over-the-counter doses with placebo for treatment of GORD in adults and reported outcomes of interest (see below). 14 RCTs involving 18 comparisons (n = 7021) met the …
For correspondence: Dr H B El-Serag, Houston Veterans Affairs Medical Center, Houston, TX, USA.
Source of funding: no external funding.