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Review: over-the-counter medications are effective for gastro-oesophageal reflux disease

https://doi.org/10.1136/ebn.10.3.76

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    Tran T, Lowry AM, El-Serag HB. Meta-analysis: the efficacy of over-the-counter gastro-oesophageal reflux disease therapies. Aliment Pharmacol Ther 2007;25:143–53.OpenUrlPubMedWeb of Science

    Q Are over-the-counter medications effective for gastro-oesophageal reflux disease (GORD)?

    METHODS

    Embedded ImageData sources:

    Medline (to 2005), reference lists, abstracts of scientific meetings, and drug manufacturers.

    Embedded ImageStudy selection and assessment:

    English language randomised controlled trials (RCTs) that compared an antacid, alginate-antacid combination, or histamine-2 receptor antagonist (H2RA) at over-the-counter doses with placebo for treatment of GORD in adults and reported outcomes of interest (see below). 14 RCTs involving 18 comparisons (n = 7021) met the …

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    Footnotes

    • For correspondence: Dr H B El-Serag, Houston Veterans Affairs Medical Center, Houston, TX, USA. hasheme{at}bcm.tmc.edu

    • Source of funding: no external funding.