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Review: antihistamines, decongestants, or both do not provide benefit in children with otitis media with effusion

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Q Are antihistamines, decongestants, or both effective in treating children with otitis media with effusion (OME)?


Embedded ImageData sources:

Cochrane Ear, Nose, and Throat Disorders Group Trials Register, Cochrane Central Register of Controlled Trials, Medline (1951–2006), EMBASE/Excerpta Medica (1974–2006), grey literature database, references of included trials and relevant reviews, manufacturers of decongestants and antihistamines, and authors in the field.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) comparing oral or nasal decongestants or antihistamines with no medication or placebo in children ⩽18 years of age with OME. Trials in which the data of patients with acute otitis media, anatomical deformity, or other chronic …

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  • For correspondence: Dr G Griffin, Quinte West Medical Centre, Trenton, Ontario, Canada. ghgriffin{at}

  • Source of funding: no external funding.