Article Text

Download PDFPDF
Postoperative ibuprofen increased bleeding complications in hospital and did not improve pain or physical function at 6–12 months after total hip replacement

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

OpenUrlAbstract/FREE Full Text

Q In patients having total hip replacement surgery, does 14 days of postoperative ibuprofen (as prophylaxis for ectopic bone formation) reduce pain and improve physical function 6–12 months after surgery? What are the effects on bleeding complications?


Embedded ImageDesign:

randomised, placebo controlled trial (HIPAID).

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients, healthcare providers, data collectors, outcome assessors, data analysts, and monitoring committee}.*

Embedded ImageFollow up period:

6–12 months after surgery {median 7.8 mo}.*

Embedded ImageSetting:

20 hospitals in Australia and New Zealand.

Embedded ImagePatients:

902 patients (mean age 66 y, 54% men) who were identified within 24 …

View Full Text


  • * Information provided by author.

  • For correspondence: Dr M Fransen, University of Sydney, New South Wales, Australia. mfransen{at}

  • Sources of funding: National Health and Medical Research Council of Australia and Medical Benefits Fund of Australia.