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Calcium reduced loss of bone mineral density but did not prevent fractures in healthy postmenopausal women

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Q Do calcium supplements reduce loss of bone mineral density (BMD) and prevent fractures in healthy postmenopausal women?


Embedded ImageDesign:

randomised, placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {patients and clinicians}.*

Embedded ImageFollow up period:

5 years (mean 4.5 y).

Embedded ImageSetting:

{university medical centre}* in Auckland, New Zealand.

Embedded ImageParticipants:

1471 healthy postmenopausal women >55 years of age (mean age 74 y) who were not taking calcium or drugs for osteoporosis; had serum creatinine concentrations <2.3 mg/dl (0.2 mmol/l) and 25-hydroxyvitamin D >10 µg/l (25 nmol/l); and had lumbar spine BMD in the normal range for age.

Embedded ImageIntervention:

elemental calcium (as citrate), 1 g …

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  • * OpenUrlCrossRefPubMedWeb of Science

  • For correspondence: Dr I R Reid, University of Auckland, Auckland, New Zealand. i.reid{at}

  • Source of funding: supplements supplied by Mission Pharmacal, San Antonio, Texas.