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Calcium reduced loss of bone mineral density but did not prevent fractures in healthy postmenopausal women

http://dx.doi.org/10.1136/ebn.10.2.53

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    Reid IR, Mason B, Horne A, et al. Randomized controlled trial of calcium in healthy older women. Am J Med 2006;119:777–85.OpenUrlCrossRefPubMedWeb of Science

    Q Do calcium supplements reduce loss of bone mineral density (BMD) and prevent fractures in healthy postmenopausal women?

    METHODS

    Embedded ImageDesign:

    randomised, placebo controlled trial.

    Embedded ImageAllocation:

    {concealed}.*

    Embedded ImageBlinding:

    blinded {patients and clinicians}.*

    Embedded ImageFollow up period:

    5 years (mean 4.5 y).

    Embedded ImageSetting:

    {university medical centre}* in Auckland, New Zealand.

    Embedded ImageParticipants:

    1471 healthy postmenopausal women >55 years of age (mean age 74 y) who were not taking calcium or drugs for osteoporosis; had serum creatinine concentrations <2.3 mg/dl (0.2 mmol/l) and 25-hydroxyvitamin D >10 µg/l (25 nmol/l); and had lumbar spine BMD in the normal range for age.

    Embedded ImageIntervention:

    elemental calcium (as citrate), 1 g …

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    Footnotes

    • ↵* Reid IR, Horne A, Mason B, et al. J Clin Endocrinol Metabol 2005;90:3824–9.OpenUrlCrossRefPubMedWeb of Science

    • For correspondence: Dr I R Reid, University of Auckland, Auckland, New Zealand. i.reid{at}auckland.ac.nz

    • Source of funding: supplements supplied by Mission Pharmacal, San Antonio, Texas.