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  • Review: inhaled insulin provides better glycaemic control than oral hypoglycaemic agents but not better than subcutaneous insulin

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Review: inhaled insulin provides better glycaemic control than oral hypoglycaemic agents but not better than subcutaneous insulin

https://doi.org/10.1136/ebn.10.2.49

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    Ceglia L, Lau J, Pittas AG. Meta-analysis: efficacy and safety of inhaled insulin therapy in adults with diabetes mellitus. Ann Intern Med 2006;145:665–75.OpenUrlCrossRefPubMedWeb of Science

    Q In patients with diabetes, what is the relative efficacy, safety, and acceptability of inhaled insulin compared with subcutaneous (SC) insulin and oral hypoglycaemic agents?

    METHODS

    Embedded ImageData sources:

    Medline (June 2006), Cochrane Controlled Clinical Trials Register (Issue 2, 2006), reference lists, and the US Food and Drug Administration web site.

    Embedded ImageStudy selection and assessment:

    English language randomised controlled trials (RCTs) that compared inhaled insulin with SC insulin or oral hypoglycaemic agents in non-pregnant adults with type 1 or type 2 diabetes and had a duration ⩾12 weeks. 16 RCTs (n = 4023, mean age range 29–60 y, 58% men) met the selection criteria. Methodological quality was assessed based on randomisation …

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    Footnotes

    • For correspondence: Drs A G Pittas or L Ceglia, Tufts-New England Medical Center, Boston, MA, USA. apittas{at}tufts-nemc.org; lisa.ceglia{at}tufts.edu

    • Sources of funding: National Institutes of Health and Friedman New York Foundation for Medical Research.