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Review: non-steroidal anti-inflammatory drugs reduce menstrual pain and heavy bleeding associated with an intrauterine device

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Q In women using an intrauterine contraceptive device (IUD), are non-steroidal anti-inflammatory drugs (NSAIDs) effective for treatment or prevention of heavy menstrual bleeding or pain associated with IUD use?


Embedded ImageData sources:

PubMed, CENTRAL, POPLINE, LILACS, EMBASE/Excerpta Medica, CINAHL, and authors of published trials.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs) that compared an NSAID with placebo, another NSAID, or another treatment for heavy menstrual bleeding or pain associated with IUD use in reproductive age women of any gravidity and parity. 15 RCTs (8 treatment, n = 370, and 7 prevention, n = 2359) met the selection criteria. …

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  • For correspondence: Dr D Grimes, Family Health International, Durham, NC, USA. dgrimes{at}

  • Sources of funding: US Agency for International Development and National Institute of Child Health and Human Development.