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Treatment
Review: children <2 years of age with bilateral acute otitis media and children with otorrhoea benefit most from antibiotics

https://doi.org/10.1136/ebn.10.2.45

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    Rovers MM, Glasziou P, Appelman CL, et al. Antibiotics for acute otitis media: a meta-analysis with individual patient data. Lancet 2006;368:1429–35.OpenUrlCrossRefPubMedWeb of Science

    Q Which subgroups of children with acute otitis media benefit from treatment with antibiotics?

    METHODS

    Embedded ImageData sources:

    Cochrane Library, PubMed, EMBASE/Excerpta Medica, and proceedings of international symposia.

    Embedded ImageStudy selection and assessment:

    randomised controlled trials (RCTs) that compared antibiotics with placebo or no treatment in children 0–12 years of age with acute otitis media and assessed pain and fever. 6 RCTs (n = 1643, mean age 3.4 y [range 0–11], 50% boys) met the selection criteria, and the authors were willing to supply raw data. Quality assessment based on 4 criteria (randomisation procedure; allocation concealment; follow up; and blinding of patients, caregivers, and outcome assessors) showed …

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    Footnotes

    • For correspondence: Dr M M Rovers, Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands. M.Rovers{at}umcutrecht.nl

    • Sources of funding: Dutch College of General Practitioners and the Netherlands Organisation for Health Research and Development.