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Environmental and dietary interventions in the first 5 years of life did not reduce the risk of asthma and allergic disease

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Q Does reduction in exposure to house dust mite (HDM) allergens and modification of dietary fatty acids in the first 5 years of life reduce the risk of asthma at 5 years of age?


Embedded ImageDesign:

randomised, 2×2 factorial, placebo controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

blinded {participants [diet intervention only] and outcome assessors}.*

Embedded ImageFollow up period:

5 years.

Embedded ImageSetting:

{recruitment in antenatal clinics of 6 hospitals in Sydney, Australia}.* Interventions were done in children’s homes.

Embedded ImageParticipants:

616 pregnant women (mean age 29 y), whose unborn singleton child was at increased risk of developing asthma because of asthma in a first degree relative. Infants born at <36 weeks’ gestation, with birth weight <2.5 kg or significant congenital malformation or …

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  • For correspondence: Dr G B Marks, Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia. g.marks{at}

  • Sources of funding: National Health and Medical Research Council of Australia and New South Wales Department of Health.