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  • Vaccinating infants with a wide long needle achieved comparable immune response and reduced local reactions compared with a narrow short needle

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Vaccinating infants with a wide long needle achieved comparable immune response and reduced local reactions compared with a narrow short needle

https://doi.org/10.1136/ebn.10.2.43

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    Diggle L, Deeks JJ, Pollard AJ. Effect of needle size on immunogenicity and reactogenicity of vaccines in infants: randomised controlled trial. BMJ 2006;333:571.OpenUrlAbstract/FREE Full Text

    Q Is vaccination of infants with a wide long needle equivalent or superior to a narrow short needle for immune response and local reactions?

    METHODS

    Embedded ImageDesign:

    randomised controlled non-inferiority trial.

    Embedded ImageAllocation:

    concealed.

    Embedded ImageBlinding:

    blinded (data entry clerks and laboratory staff).

    Embedded ImageFollow up period:

    3 to 4.5 months.

    Embedded ImageSetting:

    18 general practices in 2 primary care trusts in the UK.

    Embedded ImageParticipants:

    696 healthy infants due to receive their first immunisation (mean age 62 d, mean weight 5300 g, 52% boys). Exclusion criteria were <37 weeks gestation, birth weight <2500 g, or treatments or conditions that could bias evaluation of immune response.

    Embedded ImageIntervention:

    vaccination with a 23 gauge, 25 mm needle (wide long needle, n = 240), a 25 gauge, 16 mm needle (narrow short needle, n = 230), or a 25 gauge, 25 mm needle (narrow long needle, …

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    Footnotes

    • For correspondence: MsL Diggle, Department of Paediatrics, University of Oxford, Oxford, UK. linda.diggle{at}paediatrics.ox.ac.uk

    • Sources of funding: National Health Service Executive South East and Becton Dickinson.