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Causation
Pregnancy within 8 months of a previous birth was associated with an increased rate of preterm birth

https://doi.org/10.1136/ebn.1.4.122

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    Basso O, Olsen J, Knudsen L, Et AL. Low birth weight and preterm birth after short interpregnancy intervals.Am J Obstet Gynecol1998 Feb;178:259–63.OpenUrlCrossRefPubMedWeb of Science

    Question Are short interpregnancy intervals, defined as ≤8 months, associated with an increased risk of low birth weight or preterm delivery?

    Design

    Cohort study.

    Setting

    Denmark.

    Participants

    10 187 women who had 2 births between 1980 and 1992. Exclusion criteria were multiple births, stillbirths, and incomplete records for birth weight and gestational age of the child.

    Assessment of risk factors

    Interpregnancy interval was defined as ≤4, 4.01–8.00, 8.01–12.00, 12.01–24.00, 24.01–36.00, and >36 months and calculated as the difference between the birthdate of the first child and estimated date of conception of the second child in the study pair. The interval 24.01–36.00 months was taken as the reference standard (odds ratio [OR] 1.0). Other risk …

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    Footnotes

    • Source of funding: Danish National Research Council.

    • For correspondence: Dr O Basso, The Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, Aarhus University, Høegh-Guldberg Gade 10, DK 8000, Aarhus C, Denmark. Fax +45 8613 1580.