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A non-prescription analgesic alleviated migraine headache pain and symptoms

https://doi.org/10.1136/ebn.1.4.118

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    Lipton RB, Stewart WF, Ryan RE, et al. Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain. Three double-blind, randomized, placebo-controlled trials.Arch Neurol1998 Feb;55:210–7.OpenUrlCrossRefPubMedWeb of Science

    Question In patients with a history of migraine headache, can a non-prescription combination product (Excedrin Extra-Strength that contains acetaminophen [paracetamol], aspirin, and caffeine) reduce migraine headache pain and symptoms?

    Design

    3 randomised, double blind, placebo controlled trials with data combined for presentation.

    Setting

    20 clinical centres in the US.

    Patients

    1357 patients (mean age 36.7 y, 79% women) with a history of confirmed migraine headaches (International Headache Society criteria). Inclusion criteria were age ≥18 years, good health, migraine headache frequency from 1 headache every 2 months to 6 each month, moderate headache pain without treatment, and vomiting <20% of the episodes. 92% of …

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    Footnotes

    • Source of funding: Bristol-Meyers Squibb Co, New York, NY.

    • For correspondence: Dr R B Lipton, Department of Neurology, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA. Fax +1 301 321 1044.

    • A modified version of this abstract appears in ACP Journal Club 1998 Sept-Oct and Evidence-Based Medicine 1988 Sept-Oct.