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Published studies of any language were identified using Medline (1966–95), Embase (1993–5), and Reference Update (1995–6). Search terms included infant/newborn, pain, analgesia, and sucrose. Recent neonatal and pain journals, conference proceedings, bibliographies, and personal files were hand searched.
Studies were selected if they were blinded randomised controlled trials; the treatment included sucrose; the pain stimulus was a common medical procedure; outcomes were behavioural, physiological, hormonal, or metabolic responses to pain; and the study population was term or preterm neonates.
3 independent raters evaluated studies for methodological quality (eg, randomisation, double blinding, and accounting for dropouts). Data were extracted on study design, sample size and characteristics, intervention (including …
Sources of funding: National Institutes of Health and Fonds de la Recherche en Sante du Quebec.
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