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Treatment
Review: sucrose reduces crying during painful procedures in newborn infants

https://doi.org/10.1136/ebn.1.3.74

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    Stevens B, Taddio A, Ohlsson A, et al.The efficacy of sucrose for relieving procedural pain in neonates—a systematic review and meta-analysis.Acta Paediatr1997 Aug;86:837–42.OpenUrlPubMedWeb of Science

    Question Is sucrose effective and safe for reducing pain during procedures in newborn infants?

    Data sources

    Published studies of any language were identified using Medline (1966–95), Embase (1993–5), and Reference Update (1995–6). Search terms included infant/newborn, pain, analgesia, and sucrose. Recent neonatal and pain journals, conference proceedings, bibliographies, and personal files were hand searched.

    Study selection

    Studies were selected if they were blinded randomised controlled trials; the treatment included sucrose; the pain stimulus was a common medical procedure; outcomes were behavioural, physiological, hormonal, or metabolic responses to pain; and the study population was term or preterm neonates.

    Data extraction

    3 independent raters evaluated studies for methodological quality (eg, randomisation, double blinding, and accounting for dropouts). Data were extracted on study design, sample size and characteristics, intervention (including …

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    Footnotes

    • Sources of funding: National Institutes of Health and Fonds de la Recherche en Sante du Quebec.

    • For article reprint: not available.