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Review: sucrose reduces crying during painful procedures in newborn infants

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Question Is sucrose effective and safe for reducing pain during procedures in newborn infants?

Data sources

Published studies of any language were identified using Medline (1966–95), Embase (1993–5), and Reference Update (1995–6). Search terms included infant/newborn, pain, analgesia, and sucrose. Recent neonatal and pain journals, conference proceedings, bibliographies, and personal files were hand searched.

Study selection

Studies were selected if they were blinded randomised controlled trials; the treatment included sucrose; the pain stimulus was a common medical procedure; outcomes were behavioural, physiological, hormonal, or metabolic responses to pain; and the study population was term or preterm neonates.

Data extraction

3 independent raters evaluated studies for methodological quality (eg, randomisation, double blinding, and accounting for dropouts). Data were extracted on study design, sample size and characteristics, intervention (including …

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  • Sources of funding: National Institutes of Health and Fonds de la Recherche en Sante du Quebec.

  • For article reprint: not available.