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To assess the effectiveness of combined oral calcium and vitamin D supplementation in reducing non-vertebral fractures and bone loss in elderly people living in the community.
3 year randomised, double blind, placebo controlled trial.
Community based study in the USA.
445 healthy people living in the community who were ≥65 years of age (55% women) were enrolled and 389 (mean age 71 y) were included in the intention to treat analysis. Exclusion criteria were current cancer or hyperparathyroidism; a kidney stone in the past 5 years; renal disease; bilateral hip surgery; bisphosphonate, calcitonin, oestrogen, tamoxifen, or …
Sources of funding: National Institutes of Health and the Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University.
For article reprint: Dr B Dawson-Hughes, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Sreet, Boston, MA 02111, USA.
Adapted from an abstract published in ACP Journal Club 1998 Mar-Apr;128:44.