New clinical information is being generated faster than practicing clinicians can effectively assimilate it. Since the gold standard of clinical information is evidence-based information, tools and techniques that facilitate both the building of evidence for practice and the application of evidence to practice are essential for practicing clinicians. As such, the Acute Care Nurse Practitioner (ACNP) program at Columbia University's School of Nursing was reconfigured to incorporate both theoretically based competency evaluation standards and strategies to foster an evidence-based practice approach to clinical care. The purpose of this article is to describe a curriculum and set of learning activities used to foster both development of clinical competency and evidence-based practice in students in the Acute Care Nurse Practitioner program.