Shortly before hospital release, the spouses of 226 male and 70 female coronary artery bypass graft patients were randomly assigned to view an optimistically slanted information tape, a tape that featured coping with more ups and downs, or no tape at all. Results indicated that women, whether as patients or as caregivers, were at elevated risk for a variety of negative outcomes during the subsequent 6 months. However, female patients who had spouses in the optimistic, mastery-tape condition were protected from the elevated levels of problems that characterized women whose spouses received only standard discharge preparation. Results are discussed in relation to research on optimism effects and work that suggests men may generally be less effective caregivers than women.