Original articleExtreme and Conventional Cardiorespiratory Events and Epidemiologic Risk Factors for SIDS
Section snippets
Participants
Of the 1082 participants in the CHIME study, the home monitoring records of 306 healthy term; 170 siblings of SIDS infants (SSIDS), 50 of whom were preterm (≤37 weeks postmenstrual age [PMA]); 152 infants with an idiopathic apparent life-threatening event (ALTE), 45 of whom were preterm; and 454 preterm infants of ≤34 weeks gestation were included in the present study. Infants were excluded from the CHIME study if they had any of the following: pneumonia confirmed by chest radiograph; home
Subject Characteristics
Smoking during pregnancy and in the neonatal period was observed in 12% of Asian, 16% of African-American, 32% of Caucasian, 4% of Hispanic, and 24% of other mothers (Table II).
Events in ALTE, SSIDS, and Preterm Infants
In the cohort ≤44 weeks PMA, the ALTE, SSIDS, and preterm infants were at significantly increased risk of at least 1 extreme event compared with healthy term infants. A comparison of SSIDS and ALTE infants with preterm infants revealed that the preterm infants had significantly more events (P = .003). The ROC result for
Discussion
This study supports our first hypothesis, that extreme events are not statistically associated with known SIDS risk factors. An excess of extreme events was not found at the time of night when infants are most likely to die. In contrast, extreme events occurred less often during the early morning, when infants tend to be at higher risk for SIDS. Moreover, Asians, the ethnic group at lowest epidemiologic risk for SIDS, exhibited a tendency toward a higher rate of extreme events.13 Healthy terms
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Supported by the National Institute of Child Health and Human Development (grants HD 29067, HD 29071, HD 28971, HD 29073, HD 29056, and HD 34625) and a generous donation from the Orange County Guild for Infant Survival.