ArticlesAntibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease
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Serum brain-derived neurotrophic factor and neurocognitive function in children with type 1 diabetes
2021, Journal of the Formosan Medical AssociationCitation Excerpt :Antibodies directed against the 65-kd isoform of GAD (GAD65) that block the conversion of glutamate to GABA, leading to low GABA levels have been associated with cognitive problems, seizure disorders, and autoimmune neurologic disorders including stiff-person syndrome, autoimmune cerebellitis and neuromyelitis optica.13 GAD65 antibodies (GAD65-Ab) are detected in about 80% of newly diagnosed type 1 diabetes patients, and they are considered to be a biomarker of type 1 diabetes-associated autoimmunity.14,15 Takagi et al. reported an elderly patient with type 1A diabetes with anti-GAD autoimmunity presenting with cognitive impairment but without the known anti-GAD-related neurological conditions.16
The prognostic significance of glutamic acid decarboxylase antibodies in patients with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation
2019, Diabetes and MetabolismCitation Excerpt :Glutamic acid decarboxylase antibodies (GADA) are highly sensitive markers for autoimmune type 1 diabetes mellitus (T1DM) in adults [4]. GADA has been associated with subclinical insulitis and progressive beta cell destruction, with approximately 80% of patients with T1DM positive for GADA [5]. In islet allo-transplantation for T1DM, increases in titers of autoantibodies including GADA have been associated with reduced longevity of the islet graft, and in islet auto-transplant we have observed one case of de novo type 1 diabetes with development of GADA after TPIAT [6,7].
Prevalence of double diabetes in youth onset diabetes patients from east Delhi and neighboring NCR region
2018, Diabetes and Metabolic Syndrome: Clinical Research and ReviewsCitation Excerpt :However Reinehr et al. who reported a higher prevalence of double diabetes (32%) have not mentioned the duration of diabetes in their study. It is unclear whether shorter duration of diabetes in these subjects resulted in a higher rate of antibody positivity [15,16], which might be an important factor underlying the difference in prevalence of double diabetes from our study. When the subjects in our study were analyzed considering the duration of diabetes we found highest antibody positive with shorter duration of diabetes mellitus.
Neurologic disorders associated with anti-glutamic acid decarboxylase antibodies: A comparison of anti-GAD antibody titers and time-dependent changes between neurologic disease and type I diabetes mellitus
2018, Journal of NeuroimmunologyCitation Excerpt :Pancreatic GAD is mainly GAD65, whereas the brain contains both isoforms. Anti-GAD antibodies have been detected in the early stage of type I diabetes mellitus (T1DM) in up to 80% of patients with the disease (Tuomilehto et al., 1994), as well as in the serum and cerebrospinal fluid (CSF) of patients with neurologic disease such as stiff person syndrome (SPS) (Solimena et al., 1988; Barker et al., 1998). Although anti-GAD antibody titers are usually low (< 100 IU/mL) in patients with T1DM, they are often high in those with SPS (Saiz et al., 2008).
Could ZnT8 antibodies replace ICA, GAD, IA2 and insulin antibodies in the diagnosis of type 1 diabetes?
2018, Current Research in Translational Medicine