ORIGINAL ARTICLEPost-thrombotic Syndrome After Primary Event of Deep Venous Thrombosis 10 to 20 Years Ago☆
Section snippets
Patients
All consecutive patients who were admitted to the Department of Angiology of an Austrian tertiary care university hospital between January 1, 1978 and December 31, 1988 with a first acute DVT in the lower extremities were identified retrospectively by admission lists. We only included patients whose diagnosis of DVT was proven by phlebography and who were treated as in-patients at the department. We excluded all patients without a documented follow-up of more than 1 year after the index event.
Definitions
Demographic Data
Within the 10-year study period, 241 patients with a first acute DVT in the leg were diagnosed by phlebography and treated as in-patients at our department. Eighty patients (33%) had to be excluded from the study because data were incomplete or patients were not eligible to follow up.
Final analysis included 161 patients, who had a well-documented follow-up period for a minimum of 1 year. The median age at time of primary DVT was 55 years (IQR 43 to 65, range 16 to 86), 86 patients (53%) were
Discussion
Besides, the risk of acute PE morbidity of patients with DVT remains high even years after the event [1], [2]. In particular, PTS may restrict patients' quality of life leading ultimately to ulceration of the effected extremity [2], [3], [4], [5], [6]. Most studies concentrated on the description of the clinical course of PTS [2], [4], [5], [6], [7], [8], whereas hardly any data on hemodynamic alterations during PTS exist. Furthermore, due to different screening methods, the published results
Acknowledgements
We thank Brigitta Schönauer for the technical assistance in performing the plethysmographic studies.
References (29)
- et al.
Valvular reflux after deep vein thrombosis: incidence and time of occurrence
J Vasc Surg
(1992) - et al.
Randomised trial of effects of compression stockings in patients with symptomatic proximal-vein thrombosis
Lancet
(1997) - et al.
A prospective controlled study of the efficiency of short-term anticoagulation therapy in patients with deep vein thrombosis of the lower extremities
J Vasc Surg
(1998) - et al.
The long-term clinical course of acute deep venous thrombosis
Ann Intern Med
(1996) Pathogenesis and pathophysiology of the post-thrombotic syndrome
Clin Implic
(1996)- et al.
Deep venous thrombosis: epidemiologic, diagnostic and therapeutic aspects
Cardiologia
(1998) - et al.
Clinical features in post-thrombotic syndrome
Wi Kli Wo
(1994) - et al.
Symptomatic deep vein thrombosis and the post-thrombotic syndrome
Haematologica
(1995) - et al.
The site of residual abnormalities in the leg veins in long-term follow-up after deep vein thrombosis and their relationship to the development of the post-thrombotic syndrome
Int Angiol
(1996) Long-term consequences of deep vein thrombosis
Haemostasis
(1998)
The natural history of deep vein thrombosis
Semin Thromb Hemostasis
Clinical and hemodynamic sequelae of deep venous thrombosis: retrospective evaluation after 7–13 years
Clin Sci
Prospective 12 year follow-up study of clinical and hemodynamic sequelae after deep vein thrombosis in low-risk patients (Zurich study)
Circulation
Erratum: venous hemodynamics during impulse foot pumping
J Vasc Surg
Cited by (130)
Postthrombotic syndrome and quality of life after deep vein thrombosis in patients treated with edoxaban versus warfarin
2022, Research and Practice in Thrombosis and HaemostasisDevelopment and validation of a clinical prediction model for post thrombotic syndrome following anticoagulant therapy for acute deep venous thrombosis
2022, Thrombosis ResearchCitation Excerpt :Villalta scale is recommended by the International Society on Thrombosis and Hemostasis (ISTH) to define the presence and severity of PTS following DVT [12]. At present, several modifiable and non-modifiable clinical risk factors of PTS have been identified including: DVT recurrence [3,13,14], proximal DVT [5,15–17], high body mass index (BMI) [5,13,15,18–22], older age [13,14], gender [5,15,21,23], presence of varicose veins [21,24], poor regulation of international normalized ratio (INR) [13,25], and type and quality of anticoagulant [13,25,26]. However, there is still a lack of a practical prediction model combining those risk factors to generate an accurate estimation of PTS in individual patients with lower extremity DVT.
Ultrasound evaluation of lower extremity chronic venous disease
2022, Venous Ulcers, Second Edition
- ☆
Poster presentation on October 31, 1999 at the European Congress of the International Union of Phlebology (UIP), 41st Annual Meeting of the German Society of Phlebology; oral presentation on May 18, 2000 at the Robert MayGedächtniskongress.