Elsevier

Obstetrics & Gynecology

Volume 91, Issue 1, January 1998, Pages 136-138
Obstetrics & Gynecology

Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix

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Objective

To evaluate the estrogen and progesterone receptor status of glassy cell carcinoma of the cervix to assess the possible implications of hormone replacement therapy in these patients.

Methods

The estrogen and progesterone receptor status of 13 glassy cell carcinomas was evaluated by immunohistochemistry using commercial monoclonal antibodies and a streptavidin-biotin detection system.

Result

No immunohistochemically detectable estrogen or progesterone receptor protein was present in tumor cells, although both receptors were identified in the adjacent normal cervical tissue.

Conclusion

The absence of estrogen and progesterone receptors in glassy cell carcinoma suggests that this tumor would not be hormonally responsive and that these patients can be safely treated with hormone replacement therapy. Further studies are indicated to confirm this observation.

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