Non-antibiotic treatments v placebo for sore throat symptoms

DrugDosagePatientsDecrease in throat pain
Ibuprofen 400 mg (1 dose) 80 adults80% at 4 hours, 70% at 6 hours
400 mg (1 dose) 20 adults47% at 2 hours
200 mg (1 dose) 18 adults32% at 2 hours
10 mg/kg (1 dose) 78 children (3.5–12.5 y)25% at 2 hours, not significant at 6 hours
10 mg/kg 3 times daily for 2 days153 children (6–12 y)56% at 2 days
Aspirin 800 mg plus caffeine, 64 mg (1 dose)139 adults75% at 1 hour
800 mg (1 dose)137 adults55% at 1 hour
Aspirin containing gum 20 men53% initially, 50% at 2 hours
Niflumic acid1000 mg/day for 4–5 days230 adults17% at 2 days, 33% at 4 days
Paracetamol1000 mg (1 dose) 81 adults50% at 3 hours, 20% at 6 hours
15 mg/kg (1 dose) 77 children (3.5–12.5 y)31% at 2 hours, not significant at 6 hours
10 mg/kg 3 times/day for 2 days154 children (6–12 y)34% at 2 days
Oral rinseBenzydamine HCl 0.15% 3 hourly 51 patients (17–74 y)42% at 3 days