Long course (LC) (7–14 d) v short course (SC) (1 d or 3 d, or a single dose [SD]) antibiotic treatment for urinary tract infection in children at 1 to 10 days*
| Outcomes | NRCTs | Comparison | Weighted event rates | RRR (95% CI) | NNT (CI) |
|---|---|---|---|---|---|
| TF | 12 | LC v SC (overall) | 9% v 16% | 48% (18 to 67) | 14 (8 to 61) |
| 10 | LC v SC (PLUTI only) | 11% v 16% | 42% (8 to 64) | 18 (9 to 203) | |
| 7 | LC v SD or 1 day | 11% v 25% | 61% (28 to 79) | 7 (5 to 15) | |
| 5 | LC v 3 day | 9% v 12% | 26% (−42 to 62) | Not significant | |
| Reinfection | 4 | LC v 3 day | 7% v 8% | 9% (−110 to 61) | Not significant |
| RRI (CI) | NNH (CI) | ||||
|---|---|---|---|---|---|
| *NRCTs = number of randomised controlled trials; TF = treatment failure; PLUTI = patients with lower urinary tract infection. Other abbreviations defined in glossary; RRR, RRI, NNT, NNH, CI, and weighted event rates calculated from data supplied by author using a random effects model. | |||||
| 6 | LC v SC (overall) | 10% v8% | 28% (−36 to 156) | Not significant | |
| 5 | LC v SC (PLUTI only) | 14% v 10% | 39% (−38 to 211) | Not significant | |
| 2 | LC v SD or 1 day | 25% v 8% | 165% (−10 to 681) | Not significant | |