Oestrogen plus progestin (Oest + Prog) v placebo for postmenopausal women*

Event rates per patient-year
Unfavourable outcomesOest + ProgPlaceboRRI (95%CI)NNH (CI)
All cardiovascular disease1.57%1.32%22% (9 to 36)348 (213 to 848)
Coronary heart disease0.37%0.30%29% (2 to 63)1152 (531 to 16 693)
Stroke0.29%0.21%41% (7 to 85)1164 (562 to 6811)
Venous thromboembolism0.34%0.16%111% (58 to 182)565 (345 to 1079)
Invasive breast cancer0.38%0.30%26% (0 to 59)1285 (567 to infinity)
Favourable outcomesRRR (CI)NNT (CI)
*Abbreviations defined in glossary; RRI, RRR, NNH, NNT, and CI calculated from hazard ratios, CIs, and control event rates in article.
Vertebral fracture0.09%0.15%34% (2 to 56)1962 (1191 to 33 358)
Hip fracture0.10%0.15%34% (2 to 55)1962 (1213 to 33 358)
Colorectal cancer0.10%0.16%37% (8 to 57)1691 (1097 to 7819)