TY - JOUR T1 - Use of antidepressants in the second trimester is associated with reduced pregnancy duration, and third trimester antidepressant use with infant convulsions JF - Evidence Based Nursing JO - Evid Based Nurs DO - 10.1136/eb-2012-101002 SP - ebnurs-2012-101002 AU - Jennifer L Payne Y1 - 2012/11/01 UR - http://ebn.bmj.com/content/early/2012/11/20/eb-2012-101002.abstract N2 - Commentary on: Hayes RM, Wu P, Shelton RC, et al. Maternal antidepressant use and adverse outcomes: a cohort study of 228 876 pregnancies. Am J Obstet Gynecol 2012; 207: 49.e1– 9.OpenUrlCrossRefPubMed Second trimester exposure to antidepressants was associated with preterm birth. Third trimester exposure was associated with infant convulsions. The absolute risk for both outcomes is extremely low and most infants will not have these complications. Decisions about whether to use antidepressants during pregnancy should include the severity of the mother's psychiatric illness. Large studies that include severity of the mother's illness need to be conducted. Approximately 10–20% of women will meet the criteria for major depressive disorder (MDD) during their lifetime, including during pregnancy.1 Rates of antidepressant exposure … ER -