TY - JOUR T1 - Cholesterol lowering with simvastatin reduced stroke in patients with, or at risk of, vascular disease JF - Evidence Based Nursing JO - Evid Based Nurs SP - 82 LP - 82 DO - 10.1136/ebn.7.3.82 VL - 7 IS - 3 A2 - , Y1 - 2004/07/01 UR - http://ebn.bmj.com/content/7/3/82.abstract N2 - Collins R, Armitage J, Parish S, et al. Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions. Lancet 2004;363:757–67.OpenUrlCrossRefPubMedWeb of Science Q Does cholesterol lowering with simvastatin reduce the incidence of stroke in patients with, or at high risk of, vascular disease? Design:randomised controlled trial (Heart Protection Study [HPS]).Allocation:{concealed}*. Blinding:blinded {patients, clinicians, and data monitoring committee}*.Follow up period:5 years.Setting:{69 hospitals in the UK}*.Patients:20 536 patients (mean age 64 y, 75% men) who had non-fasting blood total cholesterol concentrations ⩾3.5 mmol/l (135 mg/dl) and a medical history of cerebrovascular disease, coronary … ER -