TY - JOUR T1 - On demand use of β<sub>2</sub>-agonists led to better asthma control than regular use in moderate to severe asthma JF - Evidence Based Nursing JO - Evid Based Nurs SP - 14 LP - 14 DO - 10.1136/ebn.4.1.14 VL - 4 IS - 1 A2 - , Y1 - 2001/01/01 UR - http://ebn.bmj.com/content/4/1/14.abstract N2 - Richter B, Bender R, Berger M.Effects of on-demandβ2-agonist inhalation in moderate-to-severe asthma. A randomized controlled trial. J Intern Med2000 Jun;247:657–66OpenUrlCrossRefPubMedWeb of Science QUESTION: In patients with moderate to severe asthma, is on demand β2-agonist inhalation as effective and safe as regular use? Randomised {allocation concealed}*, blinded (outcome assessors and statistician), crossover trial with 24 weeks of follow up for each treatment condition.Outpatient clinic at Düsseldorf University Medical Centre, Germany.80 patients (mean age 48 y, 74% women) with moderate to severe asthma on regularly scheduled β2-agonist (minimum daily intake of 6 puffs) and corticosteroid inhalation for ≥2 years. Exclusion criteria were non-respiratory illnesses or pregnancy. 73 patients (91%) completed the study.Two 24 week periods in which patients were allocated to on demand inhalation (salbutamol or fenoterol) or regular use β2-agonists … ER -