TY - JOUR T1 - Lidocaine-prilocaine cream was more effective than placebo for pain during circumcision JF - Evidence Based Nursing JO - Evid Based Nurs SP - 9 LP - 9 DO - 10.1136/ebn.1.1.9 VL - 1 IS - 1 A2 - , Y1 - 1998/01/01 UR - http://ebn.bmj.com/content/1/1/9.abstract N2 - Taddio A, Stevens B, Craig K , Et AL. Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision. N Engl J Med 1997 Apr 24; 336 : 1197 –201. OpenUrlCrossRefPubMedWeb of Science To determine the efficacy and safety of lidocaine-prilocaine cream for reducing pain during circumcision in newborns.Randomised, double blind, placebo controlled trial with 24 hour follow up.A teaching hospital in Ontario, Canada.68 healthy white newborn babies (mean age 1.4 days) ≥ 37 weeks gestation and birth weight ≥ 2500 g undergoing circumcision. Infants with jaundice or methaemoglobinaemia, and those receiving methaemoglobin inducing, analgesic, or sedative drugs were excluded. 8 infants (12%) in the treatment group were excluded from the efficacy analysis because they were not treated under blind conditions.The infants were assigned to receive 5% lidocaine-prilocaine cream (1:1 mixture of … ER -