TY - JOUR T1 - A non-prescription analgesic alleviated migraine headache pain and symptoms JF - Evidence Based Nursing JO - Evid Based Nurs SP - 118 LP - 118 DO - 10.1136/ebn.1.4.118 VL - 1 IS - 4 A2 - , Y1 - 1998/10/01 UR - http://ebn.bmj.com/content/1/4/118.abstract N2 - Lipton RB, Stewart WF, Ryan RE, et al. Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain. Three double-blind, randomized, placebo-controlled trials.Arch Neurol1998 Feb;55:210–7.OpenUrlCrossRefPubMedWeb of Science Question In patients with a history of migraine headache, can a non-prescription combination product (Excedrin Extra-Strength that contains acetaminophen [paracetamol], aspirin, and caffeine) reduce migraine headache pain and symptoms? 3 randomised, double blind, placebo controlled trials with data combined for presentation.20 clinical centres in the US.1357 patients (mean age 36.7 y, 79% women) with a history of confirmed migraine headaches (International Headache Society criteria). Inclusion criteria were age ≥18 years, good health, migraine headache frequency from 1 headache every 2 months to 6 each month, moderate headache pain without treatment, and vomiting <20% of the episodes. 92% of … ER -