Abstract
Background
The present randomized non-blind trial was conducted to clarify the effect of analgesics on febrile responses of booster diphtheria-tetanus-whole cell pertussis (DTP) vaccine in 15–20 months old infants.
Methods
A total of 270 healthy infants were randomized to receive acetaminophen (10 mg/kg) along with DTP vaccine (group 1), 2 hours after vaccination (group 2), and after the appearance of febrile reactions or irritability following vaccination (group 3, control). In addition to study medication, if the axillary temperature was higher than 38°C or if the infant seemed to be irritable, the parents were told to give acetaminophen (10 mg/kg) and record on a diary card. Vaccinees were monitored for local and systemic reactions.
Results
The incidences of local swelling, pain and erythema were not significantly different among the 3 groups. No difference was observed in the incidence of systemic reactions including febrile responses, irritability, anorexia, and vomiting among the 3 groups during the 7 days after vaccination. Of the infants, 45.1%, 46.7% and 51.9% manifested fever (axillary temperature ≥38°C) within 24 hours after the vaccination in groups 1, 2 and 3, respectively (P>0.05). The second dose of acetaminophen was less in the control group than in the prophylactic groups (P=0.009).
Conclusions
Administration of acetaminophen along with DTP vaccine or 2 hours after vaccination does not affect the occurrence of febrile responses following booster vaccination. Unnecessary use of analgesics should be prevented.
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References
Harris G, Nolan T, Hartman L. Clinical signs associated with Triple Antigen (DTP) vaccination in infants. J Paediatr Child Health 1995;31:228–232.
Mathew JL, Babbar H, Yadav S. Reasons for nonimmunization of children in an urban, low income group in North India. Trop Doct 2002;32:135–138.
Ipp MM, Gold R, Greenberg S, Goldbach M, Kupfert BB, Lloyd DD, et al. Acetaminophen prophylaxis of adverse reactions following vaccination of infants with diphtheriapertussis-tetanus toxoids-polio vaccine. Pediatr Infect Dis J 1987;6:721–725.
Lewis K, Cherry JD, Sachs MH, Woo DB, Hamilton RC, Tarle JM, et al. The effect of prophylactic acetaminophen administration on reactions to DTP vaccination. Am J Dis Child 1988;142:62–65.
Uhari M, Hietala J, Viljanen MK. Effect of prophylactic acetaminophen administration on reaction to DTP vaccination. Acta Paediatr Scand 1988;77:747–751.
Baraff LJ, Cody CL, Cherry JD. DTP-associated reactions: an analysis by injection site, manufacturer, prior reactions, and dose. Pediatrics 1984;73:31–36.
Centers for Disease Control (CDC). Pertussis immunization; family history of convulsions and use of antipyretics—supplementary ACIP statement. MMWR 1987;36:281–282.
Behrman RE, Kliegman RM, Jenson HB. Nelson Texbook of Pediatrics, 17th ed. Philadephia: Saunders, 2004: pp2432.
Jackson LA, Dunstan M, Starkovich P, Dunn J, Yu O, Nelson JC, et al. Prophylaxis with acetaminophen or ibuprofen for prevention of local reactions to the fifth diphtheria-tetanus toxoids-acellular pertussis vaccination: a randomized, controlled trial. Pediatrics 2006;117:620–625.
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Yalçın, S.S., Gümüš, A. & Yurdakök, K. Prophylactic use of acetaminophen in children vaccinated with diphtheria-tetanus-pertussis. World J Pediatr 4, 127–129 (2008). https://doi.org/10.1007/s12519-008-0025-7
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DOI: https://doi.org/10.1007/s12519-008-0025-7