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Systematic review with meta-analysis
The effectiveness of oral dextrose gel for the treatment of neonatal hypoglycaemia remains unclear
  1. Praveen Chandrasekharan,
  2. Satyan Lakshminrusimha
  1. University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York, USA
  1. Correspondence to Professor Satyan Lakshminrusimha, Pediatrics, University at Buffalo School of Medicine and Biomedical Sciences, 219, Bryant St, Buffalo, NY 14214, USA; slakshmi{at}buffalo.edu

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Commentary on: Weston PJ, Harris DL, Battin M, et al. Oral dextrose gel for the treatment of hypoglycaemia in newborn infants. Cochrane Database Syst Rev 2016:CD011027.

Implications for practice and research

  • The effectiveness of oral dextrose gel in correcting neonatal hypoglycaemia and therefore in reducing long-term neurodevelopmental impairment, remains unclear.

  • Use of 40% oral dextrose gel for the treatment of neonatal hypoglycaemia improved maternal-infant bonding during the hospital stay and increased exclusive breast feeding after discharge.

  • More evidence about use of dextrose gel for the correction of neonatal hypoglycaemia and its impact on neurodevelopmental outcomes is required.

Context

Neonatal hypoglycaemia is a common problem and a preventable cause of neurological injury.1 Forty per cent oral dextrose gel is a novel therapy and is being increasingly used for the treatment of neonatal hypoglycaemia. A systemic review by Weston et al aimed to evaluate the available evidence on the effectiveness of dextrose gel in correcting hypoglycaemia and its impact on neurodevelopment outcomes.

Methods

A Cochrane systematic review …

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