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Implications for practice and research
Persistent pulmonary hypertension in newborns (PPHN) is rare and, despite a small increased risk when selective serotonin reuptake inhibitors (SSRIs) are used in late pregnancy, the absolute risk of PPHN remains low.
Considering the risk of relapse into depression, the available evidence does not support discontinuation of SSRIs during pregnancy due to concerns about PPHN.
Future research needs to consistently either examine or control for factors that may be associated with PPHN, including treatments for underlying maternal psychiatric illness.
Depression in pregnancy is common and has adverse effects on birth outcomes, mother–infant attachment, and the behaviour and development of infants and children.1–4 While effective …
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