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Implications for practice and research
Unless delivered in an intensive manner, lifestyle therapies generally do not yield significant and sustainable weight loss for most obese patients.
Pharmacotherapy aimed at weight loss, when used prudently and in consideration of individual benefit-to-risk balance, could be a useful addition to lifestyle interventions.
Obesity is associated with numerous complications, notably type 2 diabetes, hypertension, coronary artery disease and obstructive sleep apnoea. Weight loss of 5–10%, if maintained for 2 years or more, can lead to significant improvements in these comorbidities, especially type 2 diabetes.1 Mild-to-moderate-intensity lifestyle interventions often do not achieve clinically significant and sustained weight loss for obese patients. Pharmacotherapy is recommended as an adjunct to lifestyle therapies for achieving weight loss in patients with a body mass index (BMI) of ≥30 kg/m2, and in patients with weight-related comorbidities and a BMI of ≥27 kg/m2.
Yanovski and Yanovski conducted …
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