Late pregnancy use of selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors is associated with increased risk of postpartum haemorrhage
- Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
- Correspondence to: Professor Cande V Ananth, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, 622 West 168th Street, New York, NY 10032, USA;
Implications for research and practice
Use of antidepressant medication is associated with increased risk for postpartum haemorrhage (PPH).
Further research is needed to establish a causal role between antidepressant medication use and PPH.
Clinicians should be aware of possible increased risk of postpartum haemorrhage when treating depression during pregnancy.
Antidepressant medications are commonly used to manage psychiatric conditions in pregnancy. While extensive research related to teratogenesis and neonatal outcomes has been undertaken,1 there is relatively few data related to maternal obstetrical outcomes. Research from other specialties suggests that serotonin reuptake inhibitors (SSRIs) …