Evid Based Nurs doi:10.1136/eb-2013-101548
  • Care of people with learning disabilities
  • Cohort study

In adults with intellectual disability, discontinuation of antipsychotics is associated with reduction in weight, BMI, waist circumference and blood pressure

  1. Pierre Chue
  1. Department of Psychiatry, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
  1. Correspondence to: Professor Pierre Chue, Department of Psychiatry, Faculty of Medicine, University of Alberta, 9942-108 Street, Edmonton, Alberta, Canada T5K 2J5; pchue{at}

Commentary on:

Implications for practice and research

  • Improvement in metabolic parameters can occur after discontinuation or dose reduction of antipsychotics.

  • Discontinuation of antipsychotics does not result in worsening of behaviours in the majority of patients.

  • Patients should be regularly reviewed with respect to the appropriateness of current antipsychotic regimens.


The prevalence of psychotropic drug use, particularly antipsychotics in patients with intellectual disability (ID), is high. The use of such agents for behavioural control frequently represents off-label use and is not supported by current guidelines.1 Certain psychiatric populations are very …

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBN.
View free sample issue >>

EBN Journal Chat

The EBN Journal Chat offers readers the opportunity to participate in discussion about research articles and commentaries from Evidence Based Nursing (EBN).

How to participate >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article