Calcium supplements associated with increased risk of cardiovascular death in men but not women
- Department of Medicine, University of Auckland, Auckland, New Zealand
- Correspondence to: Dr Mark J Bolland, Department of Medicine, University of Auckland, Private Bag 92019, Auckland 1042, New Zealand;
Implications for practice and research
Calcium supplements increase cardiovascular risk.
The role of calcium supplements in the management of osteoporosis should be reconsidered.
In 2008, a randomised controlled trial (RCT) suggested that calcium supplements might increase the risk of cardiovascular events.1 Subsequent meta-analyses of RCTs examining calcium monotherapy and calcium and vitamin D confirmed these findings. In a pooled analysis of 13 RCTs of calcium with or without vitamin D (n=29 277) including 1391 patients with myocardial infarction (MI) or stroke,2 calcium increased the risk of MI by 25% and stroke by 15–20%. Xiao and colleagues explored this issue in the observational National Institutes of Health-American …