Limited evidence that single-dose oral ibuprofen plus codeine is more effective for postoperative pain than either drug alone
- Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA
- Correspondence to: Dr Eugene R Viscusi, Department of Anesthesiology, Thomas Jefferson University, 111 S 11th Street, Suite G-8490, Philadelphia, PA 19107, USA;
Implications for practice and research
Professional societies (American Society of Anesthesiology (ASA) and the European Society of Anaesthesiology (ESA)) recommend maximising non-opioid over opioid analgesics and utilising a multimodal approach to perioperative pain management.
This systematic review (SR) examines the effects of combining codeine and ibuprofen.
The authors of SR conclude that ibuprofen and codeine combinations may provide enhanced efficacy.
Future research should focus on whether combination agents provide better analgesia than their individual constituent alone.
Postoperative pain control remains challenging. Historically, there has been a reliance on opioids for pain management. The American Society of Anesthesiology's (ASA's) most recent guidelines recommend maximising non-opioid agents with around-the-clock dosing and using opioids supplementally.1 Derry and colleagues performed a meticulous SR examining the analgesic efficacy of single-dose ibuprofen and codeine …