A shorter interval between menarche and first sexual intercourse is associated with increased risk of high-grade cervical disease
- Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, USA
- Correspondence to: Dr Jennifer S Smith
Department of Epidemiology, UNC Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, 2103 McGavran-Greenberg, 135 Dauer Drive, Campus Box 7435, Chapel Hill 27599, USA;
Commentary on: Ruiz AM, Ruiz JE, Gavilanes AV, et al. for the FUTURE I and II Study Group. Proximity of first sexual intercourse to menarche and risk of high-grade cervical disease. J Infect Dis 2012;206:1887–96.
Implications for practice and research
Female adolescents with a shorter duration between the age of menarche and first sexual intercourse are at an increased risk of high-grade cervical disease.
Clinical counselling should include clear recommendations to obtain human papillomavirus (HPV) vaccination well before first intercourse to reduce the future risk of high-grade cervical lesions among sexually naïve female adolescents.
Ruiz and colleagues present associations between a shorter interval between menarche and first sexual intercourse on subsequent risk of high-grade cervical intraepithelial neoplasia (CIN-2+) or adenocarcinoma in situ among young women (16–23 years), in phase III randomised controlled trials (RCTs) in Colombia and Finland. Carcinogenic HPV infection is the main …