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In infants born extremely preterm, aspirin or NSAID use during pregnancy are associated with increased risk of quadriparetic cerebral palsy
  1. Peter H Gray
  1. Newborn Services, Mater Mothers’ Hospital, South Brisbane, Queensland, Australia
  1. Correspondence to: Dr Peter H Gray
    Newborn Services, Mater Mothers’ Hospital, Raymond Tce, South Brisbane, Queensland 4101, Australia; peter.gray{at}mater.org.au

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Commentary on: Tyler CP, Paneth N, Allred EN, et al. ELGAN Study Investigators. Brain damage in preterm newborns and maternal medication: the ELGAN study. Am J Obstet Gynecol 2012;207:192.e1–9.

Implications for practice and research

  • Maternal aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of cerebral palsy in extremely preterm infants.

  • It would seem, however, that aspirin given to women at high-risk for pre-eclampsia may be beneficial.

  • Exposure to NSAIDs should be considered with caution until further information is available.

Context

The issue of taking medications during pregnancy and the risks involved has been the topic of many reviews. Aspirin is a NSAID that is prescribed to prevent recurrent abortion and to reduce the risk of pre-eclampsia. From animal studies it has been suggested that NSAIDs when taken during pregnancy have the potential to result in perinatal brain injury.1

Methods

Data were extracted from …

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