Vitamin E increases prostate cancer risk in middle-aged men relative to placebo: no significant association observed with selenium, either alone or in combination with vitamin E
- College of Nursing, Michigan State University, East Lansing, Michigan, USA
- Correspondence to Gwen Wyatt
College of Nursing, Michigan State University, 515 W Fee Hall, East Lansing, MI 48824, USA;
Implications for practice and research
■ Clinicians should inform patients that vitamin E significantly increased the risk of prostate cancer among healthy men, and should be avoided.
■ Extended follow-up of common doses of vitamins and supplements may reveal new and critically significant findings.
The lifetime risk for prostate cancer in the USA is currently estimated to be 16%. The objective of this study was to determine the long-term effect of vitamin E and selenium on the risk of prostate cancer in healthy men who had participated in the …