Use of non-aspirin NSAIDs during pregnancy may increase the risk of spontaneous abortion
- 1Department of Medicine St. Michael's Hospital, Ontario, Canada
- 2Mount Sinai Hospital and LifeQuest Centre for Reproductive Medicine, Ontario, Canada
- 3Division of Clinical Pharmacology/Toxicology, Hospital for Sick Children, Toronto, Canada
- Correspondence to Gideon Koren
The Motherisk Program, Division of Clinical Pharmacology/Toxicology, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada;
Implications for practice and research
■ Data from this study support the assertion that the use of non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy is associated with increased risk of spontaneous abortion and should, therefore, be used with caution.
■ However, other factors such as socio-economic status and co-existing illnesses may have biased these results.
■ Further research is needed to explore the effect of taking NSAIDs during pregnancy and the other factors identified.
■ Future research should include data relating to the use of both prescription and over-the-counter NSAIDs.
NSAIDs are one of the commonest classes of drugs taken by pregnant …