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Systematic review
Are antiemetics still contraindicated for gastroenteritis in children? Solid evidence now supports the safe use of ondansetron
  1. James E Colletti
  1. Department of Emergency Medicine, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to James E Colletti
    Department of Emergency Medicine, Mayo Clinic, 200 First St, NW Rochester, MN 55902, USA; colletti.james{at}mayo.edu

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Implications for practice and research

  • In children presenting with vomiting from acute gastroenteritis, ondansetron is a reasonable therapy to allow for successful oral rehydration.

  • Further research on ondansetron and rehydration should investigate the effects of different dosing regimens, time to cessation of vomiting after antiemetic administration, as well as a cost-effectiveness analysis.

Context

Acute gastroenteritis (AGE) is a common reason for a child to require emergency care and hospitalisation. In children under the age of 5 years, dehydration secondary to AGE is responsible for as many as 200 000 hospitalisations in the USA and 24 000 in the UK each year.1 2

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