Evid Based Nurs doi:10.1136/ebnurs-2011-100411
  • Child health
  • Systematic review

Are antiemetics still contraindicated for gastroenteritis in children? Solid evidence now supports the safe use of ondansetron

  1. James E Colletti
  1. Department of Emergency Medicine, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to James E Colletti
    Department of Emergency Medicine, Mayo Clinic, 200 First St, NW Rochester, MN 55902, USA; colletti.james{at}

Commentary on:

Implications for practice and research

  • In children presenting with vomiting from acute gastroenteritis, ondansetron is a reasonable therapy to allow for successful oral rehydration.

  • Further research on ondansetron and rehydration should investigate the effects of different dosing regimens, time to cessation of vomiting after antiemetic administration, as well as a cost-effectiveness analysis.


Acute gastroenteritis (AGE) is a common reason for a child to require emergency care and hospitalisation. In children under the age of 5 years, dehydration secondary to AGE is responsible for as many as 200 000 hospitalisations in the USA and 24 000 in the UK each year.1 2

In …

Free Sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of EBN.
View free sample issue >>

EBN Journal Chat

The EBN Journal Chat offers readers the opportunity to participate in discussion about research articles and commentaries from Evidence Based Nursing (EBN).

How to participate >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article